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The organometallic complex pentamethylcyclopentadienyl rhodium 2,2'-bipyridin ([Cp(*)Rh(bpy)(H(2)O)](2+)) was applied as regeneration catalyst for cytochrome C (CytC). Direct reduction of CytC-bound Fe(III) was achieved in this model system pointing towards a potential usefulness of this concept to promote cell-free P450 catalysis. In addition, controlled in situ provision with hydrogen peroxide was performed using [Cp(*)Rh(bpy)(H(2)O)](2+) resulting in improved CytC-catalyzed sulfoxidation of thioanisol This work represents the first step towards the direct-[Cp(*)Rh(bpy)(H(2)O)](2+) catalyzed regeneration of P450 monooxygenases and peroxidases.

Original publication

DOI

10.1016/j.jinorgbio.2008.11.005

Type

Journal article

Journal

J Inorg Biochem

Publication Date

03/2009

Volume

103

Pages

313 - 315

Keywords

Catalysis, Cytochrome P-450 Enzyme System, Cytochromes c, Hydrogen Peroxide, Organometallic Compounds