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OBJECTIVE: The underlying pathophysiology of tremor in Parkinson disease (PD) is unclear; however, it is known that tremor does not appear to be as responsive to dopaminergic medication as bradykinesia or rigidity. It is suggested that serotonergic dysfunction could have a role in tremor development. METHODS: Using (11)C-DASB PET, a marker of serotonin transporter binding, and clinical observations, we have investigated function of serotonergic terminals in 12 patients with tremor-predominant and 12 with akinetic-rigid PD. Findings were compared with those of 12 healthy controls. RESULTS: Reductions of (11)C-DASB in caudate, putamen, and raphe nuclei significantly correlated with tremor severity on posture and action, but not with resting tremor. The tremor-predominant group also showed reductions of (11)C-DASB in other regions involved in motor circuitry, including the thalamus and Brodmann areas 4 and 10. CONCLUSIONS: Our findings support a role for serotonergic dysfunction in motor circuitries in the generation of postural tremor in PD.

Original publication

DOI

10.1212/WNL.0b013e318292a31d

Type

Journal article

Journal

Neurology

Publication Date

14/05/2013

Volume

80

Pages

1850 - 1855

Keywords

Aged, Female, Humans, Male, Middle Aged, Motor Cortex, Nerve Net, Parkinson Disease, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins, Severity of Illness Index, Tremor