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Pain in infants is undertreated and poorly understood, representing a major clinical problem. In part, this is due to our inability to objectively measure pain in nonverbal populations. We present and validate an electroencephalography-based measure of infant nociceptive brain activity that is evoked by acute noxious stimulation and is sensitive to analgesic modulation. This measure should be valuable both for mechanistic investigations and for testing analgesic efficacy in the infant population.

Original publication

DOI

10.1126/scitranslmed.aah6122

Type

Journal article

Journal

Sci Transl Med

Publication Date

03/05/2017

Volume

9