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Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and cubilin. Recently, studies of patients with syndromes caused by dysfunctional receptors have supported the importance of these for protein clearance of human ultrafiltrate. This review focuses on the molecular biology and physiology of the receptors and their involvement in renal pathological conditions.

Original publication

DOI

10.1152/physiol.00022.2012

Type

Journal article

Journal

Physiology (Bethesda)

Publication Date

08/2012

Volume

27

Pages

223 - 236

Keywords

Animals, Endocytosis, Humans, Kidney Tubules, Proximal, Low Density Lipoprotein Receptor-Related Protein-2, Receptors, Cell Surface