Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis

Duarte S., Woll PS., Buza-Vidas N., Chin DWL., Boukarabila H., Luís TC., Stenson L., Bouriez-Jones T., Ferry H., Mead AJ., Atkinson D., Jin S., Clark S-A., Wu B., Repapi E., Gray N., Taylor S., Mutvei AP., Tsoi YL., Nerlov C., Lendahl U., Jacobsen SEW.

<jats:title>Key Points</jats:title> <jats:p>Canonical Notch signaling is dispensable for steady-state and posttransplantation myelopoiesis, as well as stress erythropoiesis. Key lineage regulators and Notch target genes are expressed independent of canonical Notch signaling in myelo-erythropoiesis.</jats:p>

DOI

10.1182/blood-2017-06-788505

Type

Journal article

Journal

Blood

Publisher

American Society of Hematology

Publication Date

12/04/2018

Volume

131

Pages

1712 - 1719

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