Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

<jats:title>ABSTRACT</jats:title><jats:sec id="S0033291707001134_sec_a001"><jats:title>Background</jats:title><jats:p>The cognitive impairment of older depressed patients with late- as opposed to early-onset illness may show important differences, in that patients with early onset may suffer predominantly from impaired episodic memory, and those with late onset mainly from reductions of executive function and processing speed.</jats:p></jats:sec><jats:sec id="S0033291707001134_sec_a002"><jats:title>Method</jats:title><jats:p>We searched Medline and EMBASE as well as individual papers' reference lists for relevant publications, recording comparisons in neuropsychological test results between early-onset depression (EOD), late-onset depression (LOD) and healthy volunteers. Effect sizes are presented for cognitive domains, such as executive function, processing speed, episodic memory, semantic memory and mental state examination.</jats:p></jats:sec><jats:sec id="S0033291707001134_sec_a003" sec-type="results"><jats:title>Results</jats:title><jats:p>Patients with LOD showed greater reductions in processing speed and executive function than patients with EOD and controls. Both patient groups showed reduced function in all domains, except mental state, compared with controls.</jats:p></jats:sec><jats:sec id="S0033291707001134_sec_a004" sec-type="conclusion"><jats:title>Conclusion</jats:title><jats:p>Pronounced executive deficits are typical of the late-onset patients described in published studies, while episodic memory impairment is not specific to early-onset illness. Possible reasons and confounders are discussed.</jats:p></jats:sec>

Original publication

DOI

10.1017/s0033291707001134

Type

Journal article

Journal

Psychological Medicine

Publisher

Cambridge University Press (CUP)

Publication Date

12/2007

Volume

37

Pages

1693 - 1702