Successful alemtuzumab retreatment in multiple sclerosis following previous diffuse alveolar haemorrhage.

Zhao DH., Hadley G., Pisa M., Saunders P., De Luca G.

Alemtuzumab-induced diffuse alveolar haemorrhage (DAH) is a rare but serious complication in people with relapsing-remitting multiple sclerosis (RRMS). Evidence supporting retreatment despite adverse events remains limited. We report a 29-year-old female who developed DAH during the first alemtuzumab cycle and was subsequently retreated 1 year later following interdisciplinary advice from respiratory. There was no recurrence of DAH. This case report provides evidence towards retreatment feasibility with regular monitoring and low thresholds for laboratory and radiological investigations.

DOI

10.1177/13524585251365791

Type

Journal article

Publication Date

2025-12-01T00:00:00+00:00

Volume

31

Pages

1684 - 1687

Total pages

3

Keywords

Alemtuzumab, disease-modifying therapies, multiple sclerosis, relapsing /remitting, Humans, Female, Adult, Alemtuzumab, Multiple Sclerosis, Relapsing-Remitting, Hemorrhage, Immunologic Factors, Retreatment, Pulmonary Alveoli, Lung Diseases

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