Anaesthesia & Intensive Care
Our work in this research theme is organised in two main areas. One area is about developing better biomarkers of brain ‘responsiveness’ which can then be translated to anaesthetic practice and intensive care. Using a multimodal imaging approach we manipulate states of consciousness using anaesthetic agents and then probe with sensory and cognitive tasks while simultaneously collecting EEG and fMRI data.
A second area of work involves designing and running multicentre studies to test new treatments in critically ill patients. Work has included trials on the timing of tracheostomies; a study on high-frequency ventilation in patients with Acute Respiratory Distress Syndrome; a study of quality of life and functional outcome in survivors of critical illness; a trial looking to develop personalised algorithms for monitoring hospital inpatients through wireless, wearable devices; a study aiming to improve the management of patients after abdominal surgery; a trial comparing protocolised rapid treatment of sepsis with standard local treatment run by ICNARC in London; and a trial comparing methods of 'weaning' patients off a mechanical ventilator.
A new area exploring vasospasm in subarachnoid haemorrhage has recently been initiated.