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Our diagnostic lab is a University-based laboratory which principally performs autoantibody tests on live cell based assay (CBA) platforms. We work closely with the Oxford University Hospitals NHS trust Immunology laboratory (OUH).

This is a list of tests performed by our team. Screening on relevant alternate antigens supports test specificity.

TEST ANTIGEN

ALTERNATE ANTIGEN(S)

SAMPLE REQUIREMENTS

METHOD

1

Clustered AChR

MuSK and LRP4

AChR serum

MuSK and LRP4 Paired serum and CSF preferred

LIVE CBA

2

GABABR

AMPAR 1/2 and GABAAR

Paired serum and CSF preferred

LIVE CBA

3

NMDAR

Neurexin 3a and Dopamine Receptor 2 (DR2)

Paired serum and CSF preferred

LIVE CBA

4

LGI1

CASPR2 and Glycine

Paired serum and CSF preferred

LIVE CBA

5

Glycine

DPPX

Paired serum and CSF preferred

LIVE CBA

6

AQP4

MOG and Glycine

Serum preferred, CSF testing available

LIVE CBA

7

GA3

 

Paired serum and CSF preferred

RIA*

10

Neuronal Cultures**

 

Paired serum and CSF preferred

LIVE CBA

11

GFAP

 

CSF only

Fixed and permeabilised CBA

12

AMPAR 2/3 (GluR3)

 

Paired serum and CSF preferred

LIVE CBA

13

IgLON5

 

Paired serum and CSF preferred

LIVE CBA

14

Contactin2 / TAG-1

 

Paired serum and CSF preferred

LIVE CBA

15

Nodal / paranodal 4 antigen panel: Neurofascin-155, Neurofascin-186, and Contactin-1/Caspr1 †

 

Serum preferred, CSF testing available

LIVE CBA

16

Neurofascin-155, Neurofascin-140, Neurofascin-186, Contactin-1, or Caspr1 (as single antigens) †

 

Serum preferred, CSF testing available

LIVE CBA

* RIA: Radioimmunoassay

** Binding of IgG autoantibodies to the surface of live neurons in culture (either CSF or serum)

 

For prices, sample specifications and how to request any of these tests please ask at neuro.immunology@nhs.net or see https://www.ouh.nhs.uk/immunology/diagnostic-tests/neuroimmunology.aspx

† All samples received for nodal / paranodal antibodies will be initially screened on the 4 antigen panel (15). For further enquiries regarding these tests, please contact simon.rinaldi@nhs.net.

For clinical enquiries, please contact sarosh.irani@ndcn.ox.ac.uk or maria.leite@ndcn.ox.ac.uk