Our group investigates the role of risk factors in the development of multiple sclerosis through functional genetic and neuro-immunological analyses, with the aim of translating these findings into a clinical utility.
Multiple sclerosis (MS) is a disabling autoimmune disease of the central nervous system, which affects approximately 0.1% of the population with variable degrees of severity. Disease susceptibility is jointly determined by genetic predisposition and environmental contribution. However, as only a handful of genetic risk factors have been investigated beyond initial genome-wide association studies and environmental factors are largely unidentified, the exact mechanism of how these associations interact remains speculative.
Our group is seeking to understand the molecular basis for these risk factors through a multidisciplinary approach, which combines analysis of both clinical samples and humanised transgenic in vivo models.
Our goal is to develop new therapeutic avenues for MS by gaining insight into disease pathways, which can be manipulated through both novel drugs and drug repositioning.
- Functional Genetics – Functional investigation of genetic variants associated with MS susceptibility
- Neuroimmunology – Characterisation of immune cell infiltrates in the central nervous system of MS patients
- Translational Medicine – Prospects of drug repositioning in MS treatment
Karla Lam Haces-Gil – DPhil Student
Lydia Lambert – DPhil Student
Sebastian Liebau – DPhil Student