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Neurodegeneration and Inflammation Research Group

DCN

Founded in 1952

Over 150 MS-related neuropathology papers since 2001

We explore the neuropathology of multiple sclerosis and other inflammatory and neurodegenerative diseases using a multidisciplinary team approach to post-mortem brain and spinal cord tissue. The aim is that the understanding derived from these studies will translate into ideas for improved treatments for living patients.

Research strategies of our group. In the Comparative Neuropathology quadrant, we represent the different manifestations of neurodegenerative and inflammatory disease in which we are interested. In the Genetics-Pathology quadrant, we represent our interest in exploring the relationship between genes and pathologic features in post-mortem tissue. In the Transcriptomics/Proteomics-Pathology quadrant, we illustrate some current work linking multiple sclerosis pathology and its relationship to gene expression and protein alterations. In the MRI-Pathology quadrant, we illustrate axonal loss and alterations in the MRI signal of the spinal cord in multiple sclerosis. For each of these strategies, we apply rigorous quantitative neuropathological outcome measures.
Research strategies of our group. In the Comparative Neuropathology quadrant, we represent the different manifestations of neurodegenerative and inflammatory disease in which we are interested. In the Genetics-Pathology quadrant, we represent our interest in exploring the relationship between genes and pathologic features in post-mortem tissue. In the Transcriptomics/Proteomics-Pathology quadrant, we illustrate some current work linking multiple sclerosis pathology and its relationship to gene expression and protein alterations. In the MRI-Pathology quadrant, we illustrate axonal loss and alterations in the MRI signal of the spinal cord in multiple sclerosis. For each of these strategies, we apply rigorous quantitative neuropathological outcome measures.

We work closely with colleagues at the Wellcome Trust Centre for Human Genetics, Department of Physiology, Anatomy, and Genetics, FMRIB, and Immunology at Oxford, as well as the UK MS Tissue Bank at Imperial College, London, the MRI groups at the University of British Columbia and University College London, and Genetics and Genomics Sciences at Mount Sinai, New York.

Research Projects

  • Comparative Neuropathology with Cerebrovascular and Degenerative Diseases
  • Genetic-Pathology Correlations
  • Transcriptomic/Proteomic-Pathology Correlations
  • MRI-Pathology Correlations

FUNDERS

GMSI logo

Medical Research Council Logo

Oxford BRC

Our team (PI - Prof Gabriele DeLuca)

Selected publications

Current Group Members and Alumni

CURRENT GROUP MEMBERS

  • Dr Jonathan Attwood - Core Medical Trainee
  • Lucy Bland - FHS student
  • Catherine Foster - Visiting PhD student (University of Tasmania)
  • Joshua Frost - Medical student
  • Dr Damian Jenkins - M.D. Candidate
  • Estefania Simoes Fernandez - Visiting PhD student (University of San Paolo)
  • Dr Jonathan Spencer - Academic Foundation Doctor (University College London)
  • Dr Richard Yates - Medical student

ALUMNI

a) DPhil students

  • Dr Bryan Adriaanse
  • Dr Ruth Geraldes
  • Dr Richard Yates

b) Masters students

  • Abishek Arora
  • Sinead Brady

c) FHS students

  • Rose Alterman
  • Harry Beale
  • Celine Brandler-Spaeth
  • Georgina Colquhoun
  • Alissa Gutnikova
  • Eleanor James
  • Daniel Mort
  • Guy Niblett
  • Joseph Watson
  • Lily Watson

Oxford Brain Bank

  • Oxford Brain Bank is a large collection of donated brain and spinal cord tissue from a wide range of diseases, including multiple sclerosis and controls.
  • Telegraph news story on brain donation.

    Videos (Grant for MS Innovation)

    Prof Gabriele DeLuca speaks to Grant for MS Innovation (Merck Serono) scientific committee chair, Prof David Bates, about his study entitled 'Molecular markers of multiple sclerosis disease progression.' Watch video

    Prof Gabriele DeLuca provides a scientific platform presentation outlining the research strategy for his recently awarded Grant for MS Innovation (Merck Serono) grant. Watch video

    Related research themes

    Neuropathology is at the interface of clinical and basic neurosciences.
    Neuropathology