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Developing methods to accurately and objectively measure neurological disorders such as Parkinson’s Disease and Progressive Supranuclear Palsy.

A group of people in the NeuroMetrology Lab group stood outside

Our approach

Most medical conditions can be rapidly and objectively quantified using standard equipment. However, the 'gold standard' measure of many brain diseases is still a clinical rating scale, a system of points assigned by an observer based on their impression of the person's condition. Such scales show significant inter-observer variability, and they are also nonlinear, limiting the statistical analyses that can be applied to them.

The NeuroMetrology laboratory led by Professor Chrystalina Antoniades uses precise measurements of abnormalities of movement and its control in order to quantify neurodegenerative diseases. Eye movements have proved to be a particularly rich source of information because they can be evaluated quickly and reliably with equipment that is portable and therefore usable in a clinic setting. Gait and balance abnormalities are key features of several neurodegenerative diseases, and can be measured using wearable sensors, either in clinic or remotely. We are also developing methods of measurement using both manual and cognitive tests, and have shown that these can be sensitive enough to detect dysfunction in Parkinson's disease even in its very early stages.

 RESEARCH STUDIES

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Selected publications