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The Cader group identified in a large family with migraine, a deleterious mutation in the gene KCNK18, encoding a potassium channel, TRESK. They are testing the hypothesis that loss of TRESK function increases nerve cell excitability and responsiveness and thereby lowers the threshold for migraine development. Using cutting-edge techniques, they are using primary and stem cultures from patients with migraine better understand the cellular mechanisms in migraine.