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The effect of Baclofen on motor learning and brain chemistry (Ethics ref: R55534/RE003)

We are looking for volunteers to participate in a study investigating how the drug Baclofen affects our brain and our ability to learn and remember new motor tasks. We would want you to be involved in the study on 2 days, each around a week apart. In the sessions you will take one dose of either Baclofen or placebo and then you will have magnetic resonance imaging (MRI) scans. The sessions will last around 3-3.5 hours. MRI is a type of brain scan that allows us to see how the brain is organised, processes information and performs skills like speech or memory.  This scan is safe and does not involve any needles or injections.

We need right-handed volunteers between 18 and 35 years old, who do not play a musical instrument to a high level (e.g. to grade 6 or above and still taking part in regular practice). You will be asked questions about your medical history to check your suitability for an MRI scan. You must be in good health and without a history of epilepsy or any other disease affecting the brain or spinal cord. If you are pregnant you should not volunteer. Sessions will take place at the John Radcliffe or Warneford Hospital. You will be remunerated for you time.

If you are interested or would like to know more we would be happy to discuss the study further with you, please contact Ioana Grigoras at ioana.grigoras@ndcn.ox.ac.uk. Ethics Reference R55534/RE003.

Study Title: The effect of Baclofen on motor learning and brain chemistry

Study Ethics Reference: R55534/RE003

Study Researcher: Ioana Grigoras at ioana.grigoras@ndcn.ox.ac.uk