New Biochemistry Building University of Oxford South Parks Road Oxford OX1 3QU
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- Researching the molecular mechanisms underlying sleep and circadian rhythm regulation
- Group Leader
- BBSRC David Phillips Fellow
I am a BBSRC David Phillips Fellow at the Sleep and Circadian Neuroscience Institute within the Nuffield Department of Clinical Neuroscience. My group researches the molecular mechanisms that regulate circadian clock entrainment.
All organisms show 24h rhythms in their physiology and behaviour, orchestrated by a circadian clock that coordinates internal time with the external world. Our research aims to understand the molecular mechanisms by which the circadian clock picks up cues from the external environment and is set to the right time. Some of our ongoing projects are listed below.
1) The role of Salt Inducible Kinases in regulating sleep and circadian rhythms:
2) The interaction of sleep and circadian signalling pathways:
3) The effect of light and other environmental inputs on the molecular clockwork:
About me: I read for a DPhil on the mechanisms of RNA interference at Brasenose college, Oxford. I subsequently joined the Sleep and Circadian Neuroscience Institute as a Roche Post-Doctoral Fellow in to work on the circadian clock and have stayed in the unit to become a group leader. I was awarded the L’Oreal Women in Science Fellowship in 2015 and I am the founder of a spin-out company, Circadian Therapeutics, that translates some of our research into the clinical arena. I am also a mother of two and am a passionate advocate for women in STEM careers.
Enquiries from potential DPhil students welcome.
Jagannath A. et al, (2013), Cell, 154, 1100 - 1111
JAGANNATH A. et al, (2021), Nature Communications
Sanghani HR. et al, (2020), Molecular Psychiatry
Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency.
Borrmann H. et al, (2023), J Gen Virol, 104
The multiple roles of salt-inducible kinases in regulating physiology
Jagannath A. et al, (2023), Physiological Reviews, 103, 2231 - 2269
The Mycoplasma hyorhinis genome displays differential chromatin accessibility.
Taylor L. et al, (2023), Heliyon, 9
Adenosine Kinase regulates Sleep Timing and the Homeostatic Sleep Response through Distinct Molecular Pathways
Wakaf Z. et al, (2023)
Sex specific regulation of the cortical transcriptome in response to sleep deprivation
Shi T. et al, (2023)