ips-derived sensory neurons
Post doctoral research fellow
My research interests are in the fields of inherited causes of pain and the myelination of peripheral neurons.
I am using a recently developed approach to differentiate induced pluripotent stem cells (ipsc) into sensory neurons. This technique is then used to investigate genetically acquired pain disorders in culture based assays. I am also working on establishing myelinating cocultures using human ipsc-derived neurons with the aim to use these to understand the pathophysiology of demyelinating neuropathies.
Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission
Gerber S. et al, (2017), Brain, 140, 2586 - 2596
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source
Weir GA. et al, (2017), Brain, 140, 2570 - 2585
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination
Clark AJ. et al, (2017), Brain, 140, 898 - 913