IPS-Derived Sensory Neurons
Postdoctoral Research Fellow
My research interests are in the fields of inherited causes of pain and the myelination of peripheral neurons.
I am using a recently developed approach to differentiate induced pluripotent stem cells (ipsc) into sensory neurons. This technique is then used to investigate genetically acquired pain disorders in culture based assays. I am also working on establishing myelinating cocultures using human ipsc-derived neurons with the aim to use these to understand the pathophysiology of demyelinating neuropathies.
An iPSC model of Hereditary Sensory Neuropathy type-1 reveals Serine responsive deficits in neuronal ganglioside composition and axoglial interactions
CLARK A., (2021), Cell Reports Medicine
Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
Establishing Myelinating Cocultures Using Human iPSC-Derived Sensory Neurons to Investigate Axonal Degeneration and Demyelination
Clark AJ., (2020), 111 - 129
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett DL. et al, (2019), Physiological Reviews, 99, 1079 - 1151
Defining the Functional Role of NaV1.7 in Human Nociception
McDermott LA. et al, (2019), Neuron, 101, 905 - 919.e8