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Senior Postdoctoral Research Scientist
After completing a BSc in Biology at Imperial College London, Alun gained a PhD in Neuroscience from the Faculty of Life Sciences, University of Manchester. Following a career development fellowship at the Mammalian Genetics Unit, MRC Harwell, he joined the University of Oxford in 2009. Currently he is a Senior Postdoctoral Researcher in a group dedicated to finding new treatments for blindness, particularly in patients with incurable retinal diseases, through clinical and laboratory research.
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.
MacLaren RE. et al, (2014), Lancet, 383, 1129 - 1137
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo
Tolmachova T. et al, (2013), Journal of Molecular Medicine, 91, 825 - 837
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Singh MS. et al, (2013), Proc Natl Acad Sci U S A, 110, 1101 - 1106
Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.
Barnard AR. et al, (2011), Exp Eye Res, 93, 771 - 777
Melanopsin regulates visual processing in the mouse retina.
Barnard AR. et al, (2006), Curr Biol, 16, 389 - 395
Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4(-/-) mouse and bipolar cells in the rd1 mouse and human retina ex vivo.
De Silva SR. et al, (2016), Gene Ther, 23, 767 - 774
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Potter PK. et al, (2016), Nat Commun, 7
Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.
Barnea-Cramer AO. et al, (2016), Sci Rep, 6
Visual Acuity after Retinal Gene Therapy for Choroideremia.
Edwards TL. et al, (2016), N Engl J Med, 374, 1996 - 1998
Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.
Militi S. et al, (2016), Proc Natl Acad Sci U S A, 113, 2756 - 2761