Training and Qualifications
MMACP (2017)
PhD in Neuroscience, The University of Queensland
PT OMT svomp (2006)
MManipTher, Curtin University of Technology (2005)
BSc, School for Physiotherapy Schinznach Switzerland (2001)
Research groups
Colleges
Collaborators
Annina Schmid
MMACP, MManipTher, PhD
Associate Professor
- Wellcome Clinical Career Development Fellow
Research focus
Peripheral entrapment neuropathies such as carpal tunnel syndrome or radiculopathies are common conditions that are caused by compression of a nerve as it travels through narrow anatomical spaces. Symptoms include tingling, numbness and weakness and many patients develop neuropathic pain. The first-line treatment for entrapment neuropathies is non-surgical management including physiotherapy and pharmacology. However, the effects of non-surgical management are often modest. A major road-block to delivering more effective interventions is a lack of understanding of disease mechanisms resulting in inadequate patient stratification.
My research focusses on advancing our understanding of the pathophysiology of entrapment neuropathies with the ultimate aim to develop precision physiotherapy and improve management for these patients.
My group uses entrapment neuropathies as unique model systems that allow the prospective evaluation of nerve injury and repair in the context of neuropathic pain. We use a range of methodologies including deep clinical phenotyping with quantitative sensory testing and neurophysiological methods. I have also been at the forefront in developing advanced neuroimaging methods to visualise peripheral nerves at ultra-high field strength (MR neurography). In addition, we use a range of technologies (e.g., RNA sequencing, qPCR, specialised histology) to study the cellular and molecular aspects of entrapment neuropathies. This multimodal and innovative approach allows a detailed understanding of the mechanisms underlying entrapment neuropathies and neuropathic pain in general.
Websites
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Why you cannot trust the dermatomes
Please see our recent animated video explaining why you cannot trust the dermatomes
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What is sciatica?
Have a look at our short video explaining what 'sciatica' is for patients
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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Here you can see our video summary explaining our findings on a gene related to human nerve regeneration
nodes of Ranvier in human skin
Key publications
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Journal article
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
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Journal article
Lewis KJ. et al, (2020), Journal of Physiotherapy, 66, 97 - 104
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Journal article
Schmid AB. et al, (2014), Brain, 137, 3186 - 3199
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Journal article
Wiberg A. et al, (2019), Nature Communications, 10
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Journal article
Schmid AB. et al, (2018), Investigative Radiology, 53, 705 - 713
Recent publications
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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
Journal article
Barrett JR. et al, (2020), Nature Medicine
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Occupational Therapists, Physiotherapists and Orthopaedic Surgeons Agree on the Decision for Carpal Tunnel Surgery
Journal article
Lewis K. et al, (2020), International Journal of Health Policy and Management
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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Journal article
Voysey M. et al, (2020), The Lancet
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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Journal article
Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993
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Somatosensory profiles in patients with non-specific neck-arm pain with and without positive neurodynamic tests
Journal article
Ottiger-Boettger K. et al, (2020), Musculoskeletal Science and Practice, 50, 102261 - 102261
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Central Sensitization in Musculoskeletal Pain: Lost in Translation?
Journal article
van Griensven H. et al, (2020), Journal of Orthopaedic & Sports Physical Therapy, 50, 592 - 596
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Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy
Journal article
Matesanz L. et al, (2020), Pain
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Physiotherapy for people with painful peripheral neuropathies: a narrative review of its efficacy and safety
Journal article
Jesson T. et al, (2020), PAIN Reports, 5, 1 - e834
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Entrapment neuropathies: a contemporary approach to pathophysiology, clinical assessment, and management
Journal article
Schmid AB. et al, (2020), PAIN Reports, 5, e829 - e829
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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth
Journal article
Baskozos G. et al, (2020), Brain, 143, 2009 - 2026
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Small fibre pathology in chronic whiplash‐associated disorder: A cross‐sectional study
Journal article
Farrell SF. et al, (2020), European Journal of Pain, 24, 1045 - 1057
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Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial
Journal article
Lewis KJ. et al, (2020), Journal of Physiotherapy, 66, 97 - 104
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Neurodynamik – Was wissen wir heute?
Journal article
Tampin B. and Schmid A., (2020), manuelletherapie, 24, 9 - 14
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A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome
Journal article
Wiberg A. et al, (2019), Nature Communications, 10
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Concurrent validity of a low‐cost and time‐efficient clinical sensory test battery to evaluate somatosensory dysfunction
Journal article
Zhu GC. et al, (2019), European Journal of Pain, 23, 1826 - 1838
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Novel Genetic Evidence That Increased Body Mass Index Has a Causal Role in the Development of Carpal Tunnel Syndrome
Conference paper
Smillie R. et al, (2019), BRITISH JOURNAL OF SURGERY, 106, 5 - 5
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Molecular and cellular correlates of human nerve regeneration: ADCYAP1 encoding PACAP enhances sensory neuron outgrowth
Journal article
Schmid AB. et al, (2019)
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Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteers
Journal article
Schmid AB. et al, (2019), BMJ Open, 9, e025530 - e025530
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Feasibility of Diffusion Tensor and Morphologic Imaging of Peripheral Nerves at Ultra-High Field Strength
Journal article
Schmid AB. et al, (2018), Investigative Radiology, 53, 705 - 713
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Sensory profiles are comparable in patients with distal and proximal entrapment neuropathies, while the pain experience differs
Journal article
Tampin B. et al, (2018), Current Medical Research and Opinion, 34, 1899 - 1906