Arantxa Bolinches Amorós
Postdoctoral Research Scientist
Arantxa’s research background is in molecular and cell biology. She did her PhD Thesis at Biomedicine Institute of Valencia (IBV-CSIC), Spain, in the field of molecular and cellular bases of rare diseases. Her PhD project was focused on understanding the role of mitochondria in neurodegeneration of peripheral neuropathies, specifically in Friedreich´s ataxia and Charcot-Marie-Tooth type 4A/2K diseases.
After completing her PhD, she joined the National Stem Cell Bank in the Príncipe Felipe Research Center (CIPF) in Valencia, Spain, where she combined her previous formation in molecular neurodegeneration with induced Pluripotent Stem Cell (iPSC) technology. She worked with iPSC derived from patients with retinopathies as disease models to study retinal dystrophies in these cells and their differenciated derivatives, retinal pigment epithelium (RPE) and photoreceptor cells.
Arantxa joined Professor MacLaren´s research group in 2017, working in a collaborative project with OxStem Ocular. The goal of this project is the identification of small molecules that stimulate retinal precursor cells as novel therapies for retinopathies.
Generation of a human iPSC line from a patient with retinitis pigmentosa caused by mutation in PRPF8 gene.
Lukovic D. et al, (2017), Stem Cell Res, 21, 23 - 25
Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia.
Mollá B. et al, (2016), Dis Model Mech, 9, 647 - 657
Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolism.
Bolinches-Amorós A. et al, (2014), Front Cell Neurosci, 8
Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans.
González-Cabo P. et al, (2011), J Biol Chem, 286, 21304 - 21314
Differential expression of PGC-1α and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts.
García-Giménez JL. et al, (2011), PLoS One, 6