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Cristina Martinez
BSc, MSc, PhD (cum laude)
Postdoctoral Research Scientist
Cristina is a postdoctoral research scientist specializing in gene therapy for retinal diseases. Since 2016, she has been an integral member of the Nuffield Laboratory of Ophthalmology at the University of Oxford, where she focuses on developing advanced gene therapies for inherited retinal dystrophies, particularly X-linked retinitis pigmentosa. Cristina also serves as the Local Biological Safety Officer for retinal gene therapy studies at Oxford University Hospitals NHS.
Cristina completed her PhD in Biotechnology at the Polytechnic University of Valencia, where she explored the roles of oxidative stress and inflammation in retinitis pigmentosa. Her research involved setting up innovative models using porcine and macaque eyes, alongside cell lines, to study retinal function and disease.
Her work has been widely published in leading scientific journals, and also recognized with numerous awards, including the Ruskell Medal (2023) for outstanding research in ophthalmology and the Thomas Willis Intermediate Career Researcher Prize (2023) from the Nuffield Department of Clinical Neurosciences.
Recent publications
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Gene Therapies in Clinical Development to Treat Retinal Disorders
Journal article
McClements ME. et al, (2024), Molecular Diagnosis & Therapy
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A hypomorphic variant of choroideremia is associated with a novel intronic mutation that leads to exon skipping
Journal article
Waldock WJ. et al, (2024), Ophthalmic Genetics, 45, 210 - 217
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Gene Therapy Trial on X-Linked Retinitis Pigmentosa Caused by Mutations in RPGR
Chapter
de la Camara CM-F. et al, (2024), Essentials in Ophthalmology, 271 - 283
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Outcomes and Adverse Effects of Voretigene Neparvovec Treatment for Biallelic RPE65-Mediated Inherited Retinal Dystrophies in a Cohort of Patients from a Single Center
Journal article
Kiraly P. et al, (2023), Biomolecules, 13, 1484 - 1484
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Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?
Journal article
Martinez-Fernandez de la Camara C. et al, (2023), Journal of Histochemistry & Cytochemistry, 71, 301 - 320
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Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations
Journal article
von Krusenstiern L. et al, (2023), JAMA Ophthalmology, 141, 275 - 275
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Is RPGR-related retinal dystrophy associated with systemic disease? A case series
Journal article
Han RC. et al, (2023), Ophthalmic Genetics, 1 - 8
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Impaired glutamylation of RPGR ORF15 underlies the cone-dominated phenotype associated with truncating distal ORF15 variants
Journal article
Cehajic-Kapetanovic J. et al, (2022), Proceedings of the National Academy of Sciences, 119
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Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa
Journal article
Martinez-Fernandez de la Camara C. et al, (2022), Expert Opinion on Emerging Drugs, 27, 431 - 443
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Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
Journal article
Orlans HO. et al, (2021), Nature Communications, 12