Professor of Intensive Care Medicine
- Senior Clinical Lecturer & Consultant Intensivist
My research work centres on large multicentre clinical trials and cohort studies involving patients treated in intensive care units, with an emphasis on treatments for respiratory conditions. Our research group runs our own studies, and we actively participate as co-applicants in studies run from other centres.
The research group also has a strong link with the Institute of Biomedical Engineering. We investigate ways to locate patterns in physiological variables ('vital signs') which precede and predict clinical deterioration in hospitalised patients. This work is based on thousands of recordings of patients' vital signs in Oxford and elsewhere. As hospitals evolve electronic patient records, this work is being expanded beyond vital signs to include many more electronically-recorded descriptors of a patient’s condition.
Our research group also has an interest in the patient’s journey both during a stay in intensive care, and afterwards in the hospital and in their home. Current research work is looking at the effect of environmental noise on intensive care units on sleep patterns and delirium, with an overall goal of significantly reducing the ambient noise. On a longer time scale, we also look at the long-term effects of critical illnesses on patients’ quality of life.
Measuring sleep in the intensive care unit: Electroencephalogram, actigraphy, or questionnaire?
Darbyshire JL. et al, (2020), Journal of the Intensive Care Society, 21, 22 - 27
Patient centred variables with univariate associations with unplanned ICU admission: a systematic review
Malycha J. et al, (2019), BMC Medical Informatics and Decision Making, 19
The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study
Palmer E. et al, (2019), American Journal of Respiratory and Critical Care Medicine, 200, 1373 - 1380
Findings of a feasibility study of pre-operative pulmonary rehabilitation to reduce post-operative pulmonary complications in people with chronic obstructive pulmonary disease scheduled for major abdominal surgery.
Marlow L. et al, (2019)
Risk factors for new-onset atrial fibrillation on the general adult ICU: A systematic review
Bedford JP. et al, (2019), Journal of Critical Care, 53, 169 - 175