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Esther Becker

PhD MSc


Professor of Translational Neuroscience

Esther graduated from the University of Amsterdam cum laude with a MSc degree in Medical Biology in 2000.  She then joined the Biomedical and Biological Sciences program at Harvard University, where she performed her PhD training with Azad Bonni. Her work as a graduate student has made significant contributions to our understanding of the specific signaling mechanisms that regulate cell death in the nervous system, particularly in the developing cerebellum. For her graduate studies, Esther was awarded a PhD Fellowship from the Boehringer Ingelheim Fonds and an Albert J. Ryan Foundation Fellowship.

After completing her PhD in 2006, Esther joined Kay Davies’ group in the Department of Physiology, Anatomy and Genetics, having been awarded a Human Frontier Science Program Fellowship and later an OXION Training Fellowship. In 2010, Esther was awarded a prestigious Dorothy Hodgkin Research Fellowship from the Royal Society to establish her own research programme, focussing on the genetic and molecular underpinnings of cerebellar ataxia in mice and humans.  Esther joined the Nuffield Department of Clinical Neurosciences in 2020. She is also Co-Director of the Oxford Interdisciplinary Bioscience Doctoral Training Partnership and the newly awarded Interdisciplinary Life and Environmental Science Landscape Award (ILESLA). Esther is Official Fellow (Cellular Life) at Reuben College.

The Becker group aims to understand the genetic, molecular and cellular mechanisms that underlie neurodevelopmental and neurodegenerative diseases of the cerebellum with the ultimate aim of developing better treatments for these disorders.

Key publications

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells

Journal article

Watson LM. et al, (2018), The Cerebellum, 17, 419 - 427

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44

Journal article

Watson LM. et al, (2017), The American Journal of Human Genetics, 101, 451 - 458

The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum

Journal article

Dulneva A. et al, (2015), Human Molecular Genetics, 24, 4114 - 4125

Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?

Journal article

Fogel BL. et al, (2015), Movement Disorders, 30, 284 - 286

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

Journal article

Becker EBE. et al, (2009), Proceedings of the National Academy of Sciences, 106, 6706 - 6711

Recent publications

Stem cell-derived in vitro models of human cerebellar development.

Chapter

Borges da Silva T. et al, (2026), 167, 301 - 333

Generating cerebellar organoids from pluripotent stem cells.

Journal article

Becker EBE. et al, (2026), Dis Model Mech, 19

In Vitro Models of Neurodegenerative Diseases

Chapter

Saleh A. and Becker EBE., (2026), Part F2033, 171 - 211

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

Journal article

Apsley EJ. et al, (2025), Disease Models & Mechanisms, 18

More publications