- Neural Injury Group Research Group
A modified glutamate-gated chloride channel GluCl delivered via AAV to the dorsal root ganglion
Post-doctoral Research Fellow
My research interests centre on understanding sensory neuron biology in health and disease. Sensory neurons of the dorsal root ganglia are an incredibly heterogeneous population of neurons; tasked with detecting a range of sensations including touch, itch, warmth and nociception. While much knowledge has been accrued as to the molecular profile of neurochemically distinct sensory neurons, the functional roles they play in normal sensation are still unclear. Less still is understood as to which populations contribute to different aspects of pathological pain following inflammation or damage to the nervous system. Better knowledge of the neural circuits underlying normal nociception and pathological pain states will undoubtedly lead to advances in the development of novel and specific analgesics.
I am particularly interested in using new tools available to neuroscience in order to control the activity of discreet neuronal populations. In doing so we can begin to ask fundamental questions as to the role of specifically targeted neurons. We have used a chemogenetic approach to remotely silence sensory neurons in a non-biased manner. This strategy has efficacy in reversing pain-related hypersensitivity in a preclinical nerve injury model. Our current work involves targeting our silencing to discreet populations in order to understand their function in normal and diseased states.
Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
Weir GA. et al, (2017), Brain, 140, 2570 - 2585
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Dafinca R. et al, (2016), Stem Cells, 34, 2063 - 2078
A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia.
Sleigh JN. et al, (2016), BMC Res Notes, 9
Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK.
Wright PD. et al, (2013), Biochem Biophys Res Commun, 441, 463 - 468
Cloxyquin (5-Chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK.
Wright PD. et al, (2013), Biochem Biophys Res Commun