Senior Postdoctoral Scientist
I joined Prof. Lars Fugger’s research group in 2013 as a postdoctoral research associate. Here I set up the use of CRISPR genome editing in the laboratory to allow us to examine the role of single nucleotide polymorphisms (SNPs) identified by GWAS studies to be associated with Multiple Sclerosis. Since then I have continued to work on functional genetics over a number of projects relating to Multiples Sclerosis associated SNPs within the immune compartment. I have experience of a wide range of technologies including flow cytometry, cell sorting, genome editing, molecular biology, tissue culture, and single cell RNA profiling.
Previously I completed my PhD on the induction, function and regulation of human Th17 cells under the supervision of Prof. Leonie Taams at King’s College London (2005-2010). Following this I worked as a Postdoctoral research associate with Prof. Taams in the newly created Centre for Molecular & Cellular Biology of Inflammation (CMCBI) under the directorship of Prof. Frederic Geissmann (2010-2013). Here I worked closely with academic, clinical and industrial collaborators to examine the plasticity of CD4+ T helper cells in rheumatoid arthritis and response to therapy.
Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma
Brencicova E. et al, (2017), PLOS ONE, 12, e0175712 - e0175712
TNF Blockade Maintains an IL-10+ Phenotype in Human Effector CD4+ and CD8+ T Cells
Roberts CA. et al, (2017), Frontiers in Immunology, 8
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Dendrou CA. et al, (2016), Science Translational Medicine, 8, 363ra149 - 363ra149
Periodontitis-associated pathogens P. gingivalis
and A. actinomycetemcomitans
activate human CD14+
monocytes leading to enhanced Th17/IL-17 responses
Cheng W-C. et al, (2016), European Journal of Immunology, 46, 2211 - 2221
Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127lowTreg Cells in Patients With Chronic Rheumatoid Arthritis
Walter GJ. et al, (2016), Arthritis & Rheumatology, 68, 103 - 116