MRC New Investigator Research Grant (2015)
Nuffield Department of Clinical Neurosciences Research Fellow
My research involves the investigation of human motor control through transcranial electrical stimulation. My focus is on revealing the neural mechanisms underlying tremor, such as occur in Parkinson's disease and Essential Tremor, with a view to therapeutic treatment. I complement this cortical manipulation with the unique interventional opportunities afforded by deep brain stimulation to probe the subcortical contribution to these networks. By combining observational research with the manipulation of brain waves in patient cohorts and healthy volunteers I attempt to unveil the functional organisation and interaction of specific brain networks.
In 2015 John-Stuart was awarded a MRC New Investigator Research Grant, aimed at developing a non-invasive form of electrical stimulation as a realisable therapy for those afflicted with disabling tremors. The award will enable John-Stuart to pursue an independent research programme in the Nuffield Department of Clinical Neurosciences (Oxford University), while continuing his close collaboration with the MRC Brain Network Dynamics Unit to better understand the neurophysiology of tremor which informs viable treatment strategies.
I am privileged enough to enjoy active collaborations with a number of esteemed researchers, including David Halliday (Intelligent Systems Research Group, University of York), Kate Watkins (Speech and Brain Group, University of Oxford) and Marom Biksom (City College of New York).
Teaching resources are now available through the WebLearn portal
Brittain et al. (2013) Tremor suppression by rhythmic transcranial current stimulation. Current Biology, 23 (5): 436-440.
The differentiated networks related to essential tremor onset and its amplitude modulation after alcohol intake.
Pedrosa DJ. et al, (2017), Exp Neurol, 297, 50 - 61
Tremor stability index: a new tool for differential diagnosis in tremor syndromes.
di Biase L. et al, (2017), Brain, 140, 1977 - 1986
Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper.
Thut G. et al, (2017), Clin Neurophysiol, 128, 843 - 857
Distinct mechanisms mediate speed-accuracy adjustments in cortico-subthalamic networks.
Herz DM. et al, (2017), Elife, 6
Surprise disrupts cognition via a fronto-basal ganglia suppressive mechanism.
Wessel JR. et al, (2016), Nat Commun, 7
Pause for breath: Emerging tremor during syncopated deep brain stimulation.
Brittain JS., (2016), Clin Neurophysiol, 127, 1009 - 1010
Reversing motor adaptation deficits in the ageing brain using non-invasive stimulation
Panouillères MTN. et al, (2015), Journal of Physiology, 593, 3645 - 3655
Reversing motor adaptation deficits in the ageing brain using non-invasive stimulation.
Panouillères MT. et al, (2015), J Physiol, 593, 3645 - 3655
Montage matters: the influence of transcranial alternating current stimulation on human physiological tremor.
Mehta AR. et al, (2015), Brain Stimul, 8, 260 - 268
Distinguishing the central drive to tremor in Parkinson's disease and essential tremor.
Brittain JS. et al, (2015), J Neurosci, 35, 795 - 806