Jussi Tolonen is a Marie Skłodowska-Curie Fellow in Esther Becker’s lab at the Nuffield Department of Clinical Neurosciences. As a medical doctor specialising in child neurology, he is curious about the development of the cerebellum, the region of the brain that controls our movements. To uncover key genes and signalling pathways in rare genetic movement disorders affecting children, he is using protocols established in the Becker lab to produce cerebellar organoids from induced pluripotent stem cells (hiPSCs).
A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.
Tolonen J-P. et al, (2020), Cellular and molecular life sciences : CMLS, 77, 3627 - 3642
Medulloblastoma, macrocephaly, and a pathogenic germline PTEN variant: Cause or coincidence?
Tolonen J-P. et al, (2020), Molecular genetics & genomic medicine, 8
Use of psychiatric medications in schizophrenia and other psychoses in a general population sample.
Nykänen S. et al, (2016), Psychiatry research, 235, 160 - 168