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Laurel Chandler
BSc (Hons)
DPhil Student and Fight for Sight Scholar
Whilst studying towards her First Class (Hons) BSc degree in Molecular and Cellular Biology at the University of Bath, Laurel joined the MRC Protein Phosphorylation and Ubiquitylation Unit in Dundee where she undertook research into the control of gene expression.
Her keen interest in translational molecular medicine led her to join Dr Kanmin Xue, Academic Clinical Lecturer at the Nuffield Laboratory of Ophthalmology, to undertake a DPhil project investigating innate immune responses to viral infection of the retina. Both Kanmin and Laurel work integrally within Professor Robert MacLaren's research team with the aim of developing effective gene therapy for inherited retinal diseases.
Recent publications
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Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues
Journal article
Chandler LC. et al, (2019), Molecular Therapy - Methods & Clinical Development, 14, 77 - 89
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Hydroxychloroquine enhances the efficacy of retinal gene therapy
Conference paper
Chandler LC. et al, (2018), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59
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DHX15 regulates CMTR1-dependent gene expression and cell proliferation
Journal article
Inesta-Vaquera F. et al, (2018), Life Science Alliance, 1, e201800092 - e201800092
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Enhancement of AAV Transduction Using Anti-Malarial Drugs, Hydroxychloroquine and Chloroquine
Conference paper
Xue K. et al, (2018), MOLECULAR THERAPY, 26, 318 - 318
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Assessment of the relationship between CHM gene expression and rate of disease progression in choroideremia
Conference paper
Patricio MI. et al, (2017), INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58