Research groups
EDUCATION
BSc Biological Sciences, University of Rome "La Sapienza" (Italy)
MSc (merit) Molecular Biology, University of Rome "La Sapienza" (Italy)
DPhil Molecular and Cell Biology, University of Rome "La Sapienza" (Italy) - École Normale Supérieure de Lyon (France)
MSc Chemical Biology, Linköping University (Sweden)
Collaborators
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Michele Hu
Professor of Clinical Neuroscience and Consultant Neurologist
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Elizabeth Dellar
Postdoctoral Researcher
Livia Civitelli
PhD in Developmental and Cell Biology
Research fellow in Molecular Neuroscience
synucleinopathies, gut-brain axis, seeding amplification assay, extracellular vesicles
RESEARCH INTERESTS
I am a chemical biologist with a passion for amyloid chemistry, biology of amyloid proteins and mechanisms of amyloid aggregation.
My overarching focus is to understand the role of peripheral alpha-synuclein in the outcome of Parkinson´s disease, with a special attention to the gut-brain axis, and to investigate alpha-synuclein strains as a potential source for stratification of patients within synucleinopathies.
I am an expert in the seeding amplification assay (SAA) and I have been working on optimising the method to become more robust and reproducible. The main goal is to move this assay into clinic to be used in diagnostics as a biomarker to aid in early detection of Parkinson's diseaseas.
I am also interested in deepening the understanding of the role of extracellular vesicles (EVs) in the gut-brain axis, with particular attention to the bacterial-derived EVs, and the use of EVs for biomarker discovery.
Recent publications
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Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
Journal article
Lee SS. et al, (2024), eLife, 13
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Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
Preprint
Lee SS. et al, (2024)
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Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
Preprint
Lee SS. et al, (2024)
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Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha‐synuclein levels in Lewy body disease
Journal article
Hrabos D. et al, (2024), Neuropathology and Applied Neurobiology, 50
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Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
Preprint
Lee SS. et al, (2023)
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Bioorthogonally Cross‐Linked Hyaluronan‐Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication
Journal article
Jury M. et al, (2022), Advanced Healthcare Materials, 2102097 - 2102097