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Matthew Nolan

DPhil Student

I am a DPhil student in the Academic Unit of Neuropathology, working with Dr. Olaf Ansorge and Prof. Kevin Talbot.

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterised neuropathologically by the loss of both upper and lower motor neurons. My research is based around the selective vulnerability and somatic mosaicism of the motor cortex in ALS. I am using a combination of histological and genetic techniques to understand why some neurons degenerate early and aggressively, while some remain largely unaffected throughout the disease course, and whether this might correlate with small aberrations within the genome that occur after conception.