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Paula Rocktaeschel

MD


DPhil Student

  • Clarendon scholar
  • MRC-funded 

I am currently a DPhil student supervised by Prof Zameel M Cader and Prof Arjune Sen. My project focusses on neurodevelopmental causes of epilepsy using a human stem cell model of tuberous sclerosis complex (TSC). Particularly, I am interested in the impact of astrocytes on epileptogenesis in this neurodevelopmental disease which is a major cause of genetic epilepsy in children.

I completed my medical studies at University of Rostock, Germany in 2016 before starting my DPhil with the Nuffield Department of Clinical Neuroscience where I am fortunate to hold a scholarship from the Medical Research Council as well as the Clarendon Fund Oxford. Before that, I completed various internships in neurology and neurosurgery, amongst other at the National Hospital for Neurology and Neurosurgery in London, and I hope to realise my dream of becoming a scientifically trained neurologist in the future. 

Publications

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nat Neurosci. 2019 Mar;22(3):401-412.
https://www.nature.com/articles/s41593-018-0332-9


Diederichs S, Bartsch L, Berkmann JC, Fröse K, Heitmann J, Hoppe C, Iggena D, Jazmati D, Karschnia P, Linsenmeier M, Maulhardt T, Möhrmann L, Morstein J, Paffenholz SV, Röpenack P, Rückert T, Sandig L, Schell M, Steinmann A, Voss G, Wasmuth J, Weinberger ME, Wullenkord R. The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol Med. 2016 May 2;8(5):442-57. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126213/