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- Neurodegeneration and Inflammation Research Group Research Group
Graduate-entry medical student
Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system, and a leading cause of non-traumatic disability in young adults. Substantial evidence suggests that cortical tissue injury plays a key role in the progression of permanent disability in MS, which unfortunately remains refractory to conventional therapies. A greater knowledge of factors that drive pathology in the MS cortex is therefore desperately needed in order to develop novel medicines that can ameliorate disease burden in the progressive stage.
My research aims to identify factors that contribute to cortical pathology in MS, and assesses relationships therein with genetic factors, in the hope that novel disease mechanisms can be identified that are amenable to therapeutic benefit in select patient groups. To this end, I completed a DPhil in the multiple sclerosis neuropathology research group and continue to work closely with Dr Gabriele DeLuca as a post-doctoral graduate medical student.
Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?
Grussu F. et al, (2017), Ann Clin Transl Neurol, 4, 663 - 679
Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex.
Yates RL. et al, (2017), Ann Neurol, 82, 259 - 270
A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord.
Grussu F. et al, (2016), J Neurosci Methods, 273, 20 - 32
Comment: HLA-DRB1*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis
Yates RL. and DeLuca GC., (2016), Multiple Sclerosis and Related Disorders
Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis.
James RE. et al, (2016), Glia, 64, 105 - 121