Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Contact information


steven.hughes@ndcn.ox.ac.uk

Photosensitive retinal ganglion cells

Photosensitive retinal ganglion cells

Collaborators

Steven Hughes

BSc MSc PhD

Senior Postdoctoral Research Fellow

My research focuses predominantly on the role of melanopsin based signaling pathways in the retina, and determining the mechanisms of phototransduction within photosensitive retinal ganglion cells. Specific interests include the role of ion channels in melanopsin signaling events and the regulation of pRGC excitability.

Other projects include assessing the impacts of naturally occurring genetic variations (OPN4 SNPs) on melanopsin function, and examining the potential of melanopsin based optogenetic gene therapy to restore functional vision in models of retinal degeneration.

Key publications

Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells

Journal article

Hughes S. et al, (2016), Eye, 30, 247 - 254

Using siRNA to define functional interactions between melanopsin and multiple G Protein partners

Journal article

Hughes S. et al, (2015), Cellular and Molecular Life Sciences, 72, 165 - 179

Nonuniform distribution and spectral tuning of photosensitive retinal ganglion cells of the mouse retina.

Journal article

Hughes S. et al, (2013), Curr Biol, 23, 1696 - 1701

Profound defects in pupillary responses to light in TRPM‐channel null mice: a role for TRPM channels in non‐image‐forming photoreception

Journal article

Hughes S. et al, (2012), European Journal of Neuroscience, 35, 34 - 43

Recent publications

Preliminary analysis of magnetic particle techniques for activating mechanotransduction in bone cells

Conference paper

Cartmell SH. et al, (2021), Proceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering, 87 - 88

ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration

Journal article

Gilhooley MJ. et al, (2021), Experimental Eye Research, 207, 108553 - 108553

The functional characteristics of optogenetic gene therapy for vision restoration

Journal article

Lindner M. et al, (2021), Cellular and Molecular Life Sciences, 78, 1597 - 1613

The functional characteristics of optogenetic gene therapy for vision restoration

Journal article

HANKINS M. et al, (2020), Cellular and Molecular Life Sciences

Functional characterisation of naturally occurring mutations in human melanopsin

Journal article

Rodgers J. et al, (2018), Cellular and Molecular Life Sciences, 75, 3609 - 3624

Differential roles for cryptochromes in the mammalian retinal clock

Journal article

Wong JCY. et al, (2018), The FASEB Journal, 32, 4302 - 4314

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy

Journal article

De Silva SR. et al, (2017), Proceedings of the National Academy of Sciences, 114, 11211 - 11216

Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina

Journal article

Hughes S. et al, (2017), Scientific Reports, 7

Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance

Journal article

Tam SKE. et al, (2017), The Journal of Neuroscience, 37, 3555 - 3567

Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors

Journal article

Tam SKE. et al, (2016), Proceedings of the Royal Society B: Biological Sciences, 283, 20162275 - 20162275

More publications