Canomad presenting without ophthalmoplegia and responding to intravenous immunoglobulin
Kam C., Balaratnam MS., Purves A., Mills KR., Riordan‐Eva P., Pollock S., Bodi I., Munro NAR., Bennett DLH.
AbstractThe acronym CANOMAD encompasses chronic ataxic neuropathy combined with ophthalmoplegia, M protein, cold agglutinins, and anti‐disialosyl antibodies.Herein we describe 2 patients presenting with progressive ataxic neuropathy who only developed ophthalmoplegia after a significant delay post‐presentation, which in 1 case had features indicative of brainstem dysfunction. Both patients were found to have an IgM paraprotein and anti‐disialosyl antibodies. They responded to treatment with intravenous immunoglobulin, thus illustrating the importance of diagnosing this condition. Muscle Nerve, 2011