Spinal cord imaging for multiple sclerosis: Advances, priorities, and opportunities.
Laule C., Cohen-Adad J., Witt AA., De Luca GC., Granziera C., Keegan BM., Kerbrat A., Klawiter EC., Kolind S., O'Grady KP., Oh J., Schilling KG., Sivakolundu DK., Smith SA., Tozlu C., Vavasour IM., Bagnato F., Gauthier SA., Mainero C., Alonso-Ortiz E., Bakshi R., Beck ES., Brier MR., Hemond CC., Krieger S., Li DK., Shinohara RT., Henry RG., North American Imaging in Multiple Sclerosis (NAIMS) Cooperative .
The spinal cord plays a central role in the pathophysiology and clinical manifestations of multiple sclerosis (MS), yet remains under-studied compared with the brain. This review summarizes key insights from the 2025 North American Imaging in MS Spinal Cord Imaging Workshop, highlighting recent advances, ongoing challenges, and future opportunities in MS spinal cord imaging. We review pathological studies and outline the clinical relevance of spinal cord lesions and atrophy for diagnosis, prognosis, and disease monitoring, highlighting emerging biomarkers of progression independent of relapse activity. Correlations between magnetic resonance imaging, histopathology, and clinical outcomes support the validation and translational potential of advanced spinal cord imaging techniques. Finally, we discuss spinal cord-specific processing pipelines and reproducibility challenges. Collectively, these insights underscore the need to integrate advanced and quantitative spinal cord imaging into clinical trials, research studies, and-when feasible-clinical care, to fully capture the extent of MS pathology, and ultimately improve patient outcomes.