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We study why certain neuronal populations are vulnerable to neurodegeneration in Parkinson’s disease brain and whether pathological changes seen in the peripheral tissues mirror or precede what is ultimately seen in the brain, and how this can be used to develop biomarkers.
Our research aims to understand the characteristics of individual brain tumours, combining cutting edge brain imaging, molecular neuropathology and neurosurgical techniques to develop personalized approaches for first-line cancer surgery.
This cross-disciplinary research group links neuropathology, endocrinology and molecular genetics to explore how the genetics and epigenetics of pituitary tumours influences clinical characteristics and to identify targets for therapeutic intervention.
In this research area novel methodological approaches are developed for working with extremely large databases of MR images, or images and genetics, and the complex statistics required in neuroimaging.
The Pain Analgesia/Anaesthesia Imaging Neuroscience group is a multidisciplinary team of scientists and clinicians. We research how the human central nervous system generates and modulates painful experiences in acute and chronic settings.
Our group uses computer simulations and mathematical analyses to understand the information processing and activity dynamics of brain networks underlying decision making. We use these models to investigate how neural circuits work in the healthy state, how their dynamics deteriorate in neurological disorders, and how their dynamics and information processing may be best restored by treatments.
Research, diagnostic and testing service of autoantibodies associated with neurological diseases.
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We are a forward-looking dynamic group interested in all aspects of clinical and experimental epileptology with an emphasis on clinically relevant research. The Group draws together all relevant disciplines across Oxford University Hospitals and the University of Oxford.
Our aim is to understand fundamental biological processes that could inform the development of targeted therapies and innovative biomarkers in neurodegenerative and neurogenetic disorders.
We use brain imaging techniques to investigate the human visual system, both in its normal state and in disease and disorder.
Our work focuses on translating imaging analysis methods to better understand processes such as brain maturation and ageing, and with a particular emphasis on neurodegenerative disorders (Alzheimer's, Parkinson's, Huntington's, ALS) and Big Data (UK Biobank, Lifespan HCP).
The Critical Care Research Group undertakes a programme of research which focuses on the identification of early patient deterioration and long-term clinical outcomes of patients who have been admitted to an Intensive Care Unit.
We want to understand how - and why - brain function can be disturbed to lead to poor memory and loss of motivation (apathy). Our aim is to develop new treatments for these conditions across a range of neurological disorders.
Our aim is to gain a better understanding of the response of the peripheral nervous system to injury in order to develop strategies to promote peripheral nerve repair and to prevent the development of neuropathic pain. To do this we employ a variety of multi-disciplinary techniques ranging from transgenic models to human psychophysical studies and genetics.