Glycine receptor autoantibodies disrupt inhibitory neurotransmission
Crisp SJ., Dixon CL., Jacobson L., Chabrol E., Irani SR., Leite MI., Leschziner G., Slaght SJ., Vincent A., Kullmann DM.
Immunoglobulin G autoantibodies to glycine receptors are found in many patients with progressive encephalomyelitis with rigidity and myoclonus (PERM). Crisp et al. show that purified patient IgGs disrupt inhibitory neurotransmission in cultured motoneurons, and provide evidence for direct antagonistic actions on glycine receptors.