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We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.

Type

Journal article

Journal

FEBS Lett

Publication Date

20/11/2003

Volume

554

Pages

410 - 416

Keywords

Non-programmatic, Amino Acid Sequence, Animals, Brain, Exons, Eye, Genes, Genome, Humans, Kallikreins, Mice, Molecular Sequence Data, Nerve Tissue, Nerve Tissue Proteins, Organ Specificity, Phylogeny, Protein Structure, Tertiary, Sequence Alignment, Sequence Homology, Amino Acid, Species Specificity