Targeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.
Journal article
J Headache Pain
11/09/2023
24
Amylin, Anti-CGRP, Calcitonin, Headache, Migraine, Trigeminal, Humans, Antibodies, Monoclonal, Calcitonin Gene-Related Peptide Receptor Antagonists, Migraine Disorders, Receptors, Calcitonin Gene-Related Peptide, Signal Transduction