Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: Studies in animal models and epileptic patients have suggested that circuits of the basal ganglia may control epileptic seizures and that striatal dopaminergic transmission plays a key role in seizure interruption. Ring chromosome 20 (r[20]) epilepsy is a very homogenous type of epilepsy and is clinically characterized by long-lasting seizures suggesting a dysfunction in the seizure control system. The hypothesis that these long-lasting seizures are associated with a reduction of striatal dopamine was addressed in the present study in drug-resistant patients with r(20) epilepsy using PET. METHOD: The authors performed [18F]fluoro-l-DOPA PET in 14 patients with r(20) epilepsy and compared uptake constants in the putamen and the caudate with those of 10 controls. In addition, the authors examined the correlation between these constants and the percentage of cells with r(20) mosaicism. RESULTS: [18F]fluoro-l-DOPA uptake was significantly decreased bilaterally in the putamen and in the caudate nucleus of patients. This reduction was equal for both nuclei and was not correlated to the percentage of cells with r(20). CONCLUSION: Striatal dopamine is modulated in r(20) epilepsy; dysfunction of this neurotransmission may impair the mechanisms that interrupt seizures.

Type

Journal article

Journal

Neurology

Publication Date

13/07/2004

Volume

63

Pages

73 - 77

Keywords

Adolescent, Adult, Anticonvulsants, Caudate Nucleus, Chromosome Disorders, Chromosomes, Human, Pair 20, Dihydroxyphenylalanine, Dopamine, Drug Resistance, Electroencephalography, Epilepsies, Partial, Epilepsy, Epilepsy, Generalized, Epilepsy, Tonic-Clonic, Fear, Female, Humans, Intellectual Disability, Magnetic Resonance Imaging, Male, Positron-Emission Tomography, Putamen, Radiopharmaceuticals, Ring Chromosomes, Status Epilepticus, Synaptic Transmission