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Alzheimer's disease (AD) pathology is characterized by beta-amyloid plaques and neurofibrillary tangles. Studies of autosomal dominant early-onset AD mutations suggest that beta-amyloid overproduction is sufficient to cause AD. Recently, the BACE gene, which encodes beta-secretase, the rate limiting enzyme in beta-amyloid formation, has been identified. Since this gene is a strong candidate gene for late-onset AD because of its function, we have characterized its genomic organization and identified two polymorphisms. Neither of these polymorphisms were associated with AD risk in genetic association studies comparing autopsy-confirmed late-onset AD cases and age-matched non-demented controls. Thus, we find no evidence that this locus influences risk for late-onset AD.

Type

Journal article

Journal

Neuroreport

Publication Date

05/03/2001

Volume

12

Pages

631 - 634

Keywords

3' Untranslated Regions, 5' Untranslated Regions, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid Precursor Protein Secretases, Aspartic Acid Endopeptidases, Base Sequence, Endopeptidases, Female, Genetic Testing, Humans, Male, Molecular Sequence Data, Polymorphism, Genetic, RNA Splice Sites