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UNLABELLED: Substantial axon damage, detected by immunostaining for beta amyloid precursor protein (betaAPP) has been demonstrated in acute demyelinating lesions in multiple sclerosis. AIMS: The present study aimed to determine if this was also the case in the other human acute demyelinating diseases, acute hemorrhagic leucoencephalitis (AHLE), acute disseminated encephalomyelitis (ADEM) and central pontine myelinolysis (CPM). METHODS: BetaAPP immunostaining was used as a marker of axonal damage in autopsy material from these conditions. RESULTS: Axonal damage was detected in all these conditions. Its extent varied within and between them. Axonal damage was largely confined to tissue adjacent to veins and venules in AHLE and ADEM but was unrelated to proximity to these vessels in CPM. CONCLUSION: Substantial axon damage occurs in fatal cases of AHLE, ADEM and CPM.

Original publication

DOI

10.1016/j.jns.2004.03.032

Type

Journal article

Journal

J Neurol Sci

Publication Date

15/07/2004

Volume

222

Pages

29 - 34

Keywords

Acute Disease, Adult, Aged, Amyloid beta-Protein Precursor, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Axons, Biomarkers, Brain, Encephalomyelitis, Acute Disseminated, Female, Humans, Immunohistochemistry, Leukoencephalitis, Acute Hemorrhagic, Macrophages, Male, Middle Aged, Myelinolysis, Central Pontine, Spinal Cord, Veins, Wallerian Degeneration