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Damage to axons in acute multiple sclerosis (MS) lesions is now well established but the mechanisms of this damage remain obscure. Here we have applied a panel of antibodies that identify cell populations and proteins contained in them with a view to detecting those cells and proteins that are localised particularly closely to damaged axons in acute, sub-acute and border-active MS plaques. Results are expressed semi-quantitatively and graphs produced that show that many of the markers show enhanced expression at sites of axon damage. However, the sharpest increase in expression in relation to axon damage was seen for Calpain I (micro-calpain), inducible nitric oxide synthase and MMP-2, suggesting that these proteins may form part of a group of proteins responsible for the initiation of myelin and/or axon damage seen in MS lesions.

Original publication

DOI

10.1007/s00401-006-0045-0

Type

Journal article

Journal

Acta Neuropathol

Publication Date

04/2006

Volume

111

Pages

289 - 299

Keywords

Amyloid beta-Peptides, Antigens, CD, Antigens, CD3, Antigens, Differentiation, Myelomonocytic, Axons, Biomarkers, Brain, Calpain, Humans, Immunohistochemistry, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Multiple Sclerosis, Nitric Oxide Synthase Type II, Osteopontin, Plaque, Amyloid, Proteins, Sialoglycoproteins, T-Lymphocytes, Tyrosine