Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The histopathology of multiple sclerosis (MS), the most common demyelinating disorder, is the main focus of this review. MS is characterized by inflammatory demyelination, accompanied by gliosis. The MS plaque can show ongoing active demyelination, which can be accompanied by varying degrees of remyelination, or be quiescent. The current concept that MS is an autoimmune disease of myelin has been challenged by recent studies, and it is becoming increasingly clear that neurodegeneration is a significant component of the disease and may largely account for its progressive disability. Other disorders related to MS that are briefly discussed here are acute disseminated encephalomyelitis, acute haemorrhagic leucoencephalitis, neuromyelitis optica and progressive multifocal leucoencephalopathy. © 2011 Elsevier Ltd.

Original publication

DOI

10.1016/j.mpdhp.2011.02.001

Type

Journal article

Journal

Diagnostic Histopathology

Publication Date

01/05/2011

Volume

17

Pages

225 - 231