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BACKGROUND: Seronegative NMO is highly prevalent in non-Western countries implying the presence of as yet unknown antibodies (Ab). We investigated potential novel Ab in aquaporin-4 Ab (AQP-4-Ab) positive and negative NMO patients. METHODS: Sera of 20 NMO patients were examined for AQP-4, myelin oligodendrocyte glycoprotein (MOG) and glycine receptor (GlyR) Ab by cell-based assays. RESULTS: AQP-4-Ab was identified in 10 NMO patients, MOG-Ab was detected only in one AQP-4-Ab positive patient and GlyR-Ab was detected in two AQP-4-Ab negative patients. GlyR-Ab positive patients displayed simultaneous optic neuritis and transverse myelitis attacks and relatively low disability, whereas MOG and AQP-4-Ab double positive patient had a significantly increased disability. CONCLUSION: This study showed for the first time the presence of GlyR-Ab in Turkish NMO patients. In contrast with previous reports, MOG Ab does not appear to be a distinctive marker for Turkish AQP-4-Ab negative NMO patients.

Original publication

DOI

10.1016/j.jns.2013.08.034

Type

Journal article

Journal

J Neurol Sci

Publication Date

15/12/2013

Volume

335

Pages

221 - 223

Keywords

Antibody, Aquaporin-4, Glycine receptor, Myelin oligodendrocyte glycoprotein, Neuromyelitis optica, Sera, Adolescent, Adult, Antibodies, Aquaporin 4, Female, Humans, Male, Middle Aged, Myelin-Oligodendrocyte Glycoprotein, Neuromyelitis Optica, Receptors, Glycine, Turkey, Young Adult