Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.
Mäkelä KM., Traylor M., Oksala N., Kleber ME., Seppälä I., Lyytikäinen LP., Hernesniemi JA., Kähönen M., Bevan S., Rothwell PM., Sudlow C., Dichgans M., Wellcome Trust Case Control Consortium 2 (WTCCC2) None., Delgado G., Grammer TB., Scharnagl H., Markus HS., März W., Lehtimäki T.
BACKGROUND AND PURPOSE: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). METHODS: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls). RESULTS: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. CONCLUSIONS: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.