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A 28-month-old infant presented with fever, vomiting and encephalopathy. Magnetic resonance imaging findings and family history confirmed a diagnosis of recurrent familial acute necrotizing encephalopathy (ANE1). We believe that this is the first description implicating the H1N1 viral strain as a trigger and the second report of a T653I mutation in the RANBP2 gene described in relation to ANE1.

Original publication

DOI

10.1097/INF.0000000000000533

Type

Journal article

Journal

Pediatr Infect Dis J

Publication Date

03/2015

Volume

34

Pages

318 - 320

Keywords

Adult, Amino Acid Substitution, Brain, DNA Mutational Analysis, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Leukoencephalitis, Acute Hemorrhagic, Magnetic Resonance Imaging, Molecular Chaperones, Mutation, Nuclear Pore Complex Proteins