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The pathogenesis of Guillain-Barré syndrome (GBS) is considered to be, at least in part, mediated by autoantibodies directed against neuronal antigens. Antibodies to contactin-associated protein-like 2 (CASPR2), part of the voltage-gated potassium channel complex (VGKC-complex), are associated with neurological disease predominantly affecting the peripheral nervous system but are not known to be associated with GBS. We report two cases of ganglioside antibody-negative paediatric GBS associated with CASPR2 antibodies. Both patients made a complete clinical recovery. The tissue distribution and function of CASPR2 make it a biologically plausible autoimmune target in GBS and its clinical relevance in GBS should be determined in further studies.

Original publication

DOI

10.1111/jns.12089

Type

Journal article

Journal

J Peripher Nerv Syst

Publication Date

09/2014

Volume

19

Pages

246 - 249

Keywords

Guillain-Barré syndrome, contactin-associated protein-like 2, leucine-rich glioma-inactivated 1, voltage-gated potassium channel, Autoantibodies, Child, Child, Preschool, Guillain-Barre Syndrome, Humans, Male, Membrane Proteins, Nerve Tissue Proteins