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Extraretinal photoreceptors located within the medio-basal hypothalamus regulate the photoperiodic control of seasonal reproduction in birds. An action spectrum for this response describes an opsin photopigment with a λmax of ∼ 492 nm. Beyond this however, the specific identity of the photopigment remains unresolved. Several candidates have emerged including rod-opsin; melanopsin (OPN4); neuropsin (OPN5); and vertebrate ancient (VA) opsin. These contenders are evaluated against key criteria used routinely in photobiology to link orphan photopigments to specific biological responses. To date, only VA opsin can easily satisfy all criteria and we propose that this photopigment represents the prime candidate for encoding daylength and driving seasonal breeding in birds. We also show that VA opsin is co-expressed with both gonadotropin-releasing hormone (GnRH) and arginine-vasotocin (AVT) neurons. These new data suggest that GnRH and AVT neurosecretory pathways are endogenously photosensitive and that our current understanding of how these systems are regulated will require substantial revision.

Original publication

DOI

10.1016/j.yfrne.2014.11.001

Type

Journal article

Journal

Front Neuroendocrinol

Publication Date

04/2015

Volume

37

Pages

13 - 28

Keywords

Arginine-vasotocin (AVT), Birds, Gonadotropin-releasing hormone (GnRH), Hypothalamus, Neurosecretory, Opsin, Photoperiodism, Photopigment, Seasonal reproduction, VA opsin, Animals, Avian Proteins, Birds, Gonadotropin-Releasing Hormone, Hypothalamus, Opsins, Photoreceptor Cells, Vertebrate, Seasons, Sexual Behavior, Animal, Vasotocin