Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Dendrou CA., Cortes A., Shipman L., Evans HG., Attfield KE., Jostins L., Barber T., Kaur G., Kuttikkatte SB., Leach OA., Desel C., Faergeman SL., Cheeseman J., Neville MJ., Sawcer S., Compston A., Johnson AR., Everett C., Bell JI., Karpe F., Ultsch M., Eigenbrot C., McVean G., Fugger L.

Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases.

DOI

10.1126/scitranslmed.aag1974

Type

Journal article

Journal

Science Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

02/11/2016

Volume

8

Permalink Original publication