AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.
Gao X., Bashirova A., Iversen AKN., Phair J., Goedert JJ., Buchbinder S., Hoots K., Vlahov D., Altfeld M., O'Brien SJ., Carrington M.
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.