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An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

Original publication

DOI

10.1038/nm1333

Type

Journal article

Journal

Nat Med

Publication Date

12/2005

Volume

11

Pages

1290 - 1292

Keywords

Acquired Immunodeficiency Syndrome, Alleles, CD8-Positive T-Lymphocytes, Disease Progression, HIV-1, HLA-B Antigens, Humans, Survival Analysis, Time Factors